Their overall incidence is around 0.13 cases per 100 000 person-years1 and they account for 2% to 5% of all primary intracranial neoplasms.2 Growth hormone (GH)-secreting pituitary adenomas are relatively rare, with a prevalence of 50 to 70 cases/million and an incidence of 3 to 4 new cases/million/year.3–5. The gene discussed is GH1; the disease is pituitary gland adenoma.