POMC and craniopharyngioma: 21 Headache and visual field defects are the most common presenting clinical features (64% and 55%, respectively). Craniopharyngiomas can result in a high incidence of deficiencies of GH, luteinizing hormone/follicle-stimulating hormone, thyroid-stimulating hormone, and adrenocorticotropic hormone (>80%), and diabetes insipidus (65%).22