The data presented herein shows that activity of IGF-1R/IRS-1 was higher in NALM6 vs. CCRF-CEM cells, and that their expression also differs within Bp-ALL REH and SupB15 subtypes characterized by the non-random translocations t[12;21], and t[9;22]. The gene discussed is IGF1R; the disease is acute lymphoblastic leukemia.