To further assess whether IGF-1R signaling may be influenced by biological pathways closely linked to cell lineage and non-random chromosomal translocations, we have mined existing gene expression databases from childhood ALL patients http://www.stjuderesearch.org/data/ALL1, and found that the expression of relevant IGF-1 regulatory carriers such as IGFBP2 and IGFBP4 appear to be significantly differentially expressed in ALL in a phenotype specific manner. This evidence concerns the gene IGFBP4 and acute lymphoblastic leukemia.