On the other hand, neonatal diabetes due to mutations in INS (4, 17, 25) or either of the genes encoding the K-ATP subunits KIR6.2 (5) and SUR1 (6, 7) occurs de novo in approximately 50% of the cases and these subjects typically present with autoantibody-negative insulin-dependent diabetes. Here, ABCC8 is linked to type 1 diabetes mellitus.