In addition, GLRX5 is intimately involved in erythropoiesis as revealed by the following results [81]; first of all, GLRX5 is highly expressed in bone marrow and particularly in erythroid precursor cells, as shown by both bioinformatics data and in situ hybridization; secondly, GLRX5 expression is induced during erythroid differentiation, in association with two other heme synthesis proteins, ALAS2 and ferrochelatase [82, 83]; and thirdly, GLRX5 deficiency caused a sideroblastic anemia in a human patient [74] and anemia in zebrafish [76]. This evidence concerns the gene GLRX5 and sideroblastic anemia.