GLRX5 and sideroblastic anemia: GLRX5, the human ortholog of yeast GRX5, for review see [72–74], represents a member of a family of highly conserved monothiol glutaredoxins that are essential to Fe-S cluster biogenesis in yeast, plants, and mammals [75–77], and GLRX5 deficiency caused sideroblastic anemia in an Italian patient [74].