TFRC and anemia (phenotype): More directly, erythroblasts are themselves significantly dependent on proper iron homeostasis controlled by IRP2 [33, 34] and on successful iron acquisition mediated by transferrin receptor 1 (TfR1) [35] and mitoferrin-1 (or SLC25A37) [36, 37], as shown by anemias that develop when they are deficient in model organisms.