Conditional deletion of SOCS3 in T and NKT cells exacerbates ConA-induced hepatitis [46], while transgenic overexpression of SOCS3 in T and NKT cells [46, 47] or intraperitoneal administration of cell-penetrating SOCS3 in mice [48] prevents ConA-induced liver injury. The gene discussed is SOCS3; the disease is Hepatitis.