S100B and Alzheimer disease: To examine a possible role of S100B in the progression of AD-like pathology, we undertook a genetic approach to overproduce S100B by crossing transgenic mice expressing human S100B (TghuS100B mice) [86] with Tg2576 animals [127] to yield four genotypes of littermates: Tg2576, Tg2576-huS100B, TghuS100B, and wild-type.