CDH3 and cervical carcinoma: In parallel, we found that SKI-606 inhibits β-catenin phosphorylation and consequently its translocation to the nucleus in these cells (Figure 6); thus, SKI-606 blocks cell migration through the conversion of β-catenin's role from a transcriptional regulator to a cell-cell adhesion function in HeLa-cervical cancer cells and by modulating the expression patterns of many genes including P-cadherin, fascin, Id-1, IGF-R1, and EGF-R (Figure 7(a)).