In parallel, we reveal that SKI-606 and, to a lesser extent, Iressa, induces differentiation to an epithelial phenotype of HeLa and SiHa human cervical cancer cell lines; moreover, we report that Src/Abl inhibitor up-regulates and restores the expression patterns of E-cadherin as well as α-, β-, and γ-catenin in HeLa cells in comparison with untreated cells and Iressa-treated cells in which these parameters are less substantially affected. Here, CDH1 is linked to cervical cancer.