In conclusion, our study is the first evidence demonstrating that treatment with Src/Abl inhibitor and, to a lesser extent, EGF-R inhibitor induce differentiation to an epithelial phenotype and upregulates as well as restores the expression of the E-cadherin/catenin complex and subsequently inhibits cell invasion and migration of human cervical cancer cells. This evidence concerns the gene CDH1 and cervical carcinoma.