To explore the role of Src/Abl inhibitor, SKI-606, as a potential treatment for human cervical carcinomas, we compared the effect of SKI-606 with Iressa on cell proliferation, cell cycle progression, differentiation, invasion, and motility in HeLa and SiHa human cervical cancer cell lines which express E6/E7 oncoproteins of HPV types 18 and 16, respectively. Here, SRC is linked to cervical carcinoma.