Regarding the mechanism of E-cadherin/catenin complex re-localization and P-cadherin, fascin, Id-1, IGF-R1, and EGF-R gene deregulations, we hypothesized that SKI-606 provokes E-cadherin/catenin complex reassociation by blocking the phosphorylation of β-catenin through the inhibition of pp60(c-Src) kinase phosphorylation in HeLa cancer cells. The gene discussed is FSCN1; the disease is cancer.