PAX8 and thyroid cancer, nonmedullary, 2: The translocation t(2;3)(q13;p25) has been identified in FTC which results in fusion of part of the DNA-binding segment of the PAX8 gene and the peroxisome proliferator-activated receptor gamma 1 (PPAR-gamma-1) gene; PAX8 is a thyroid transcription factor, and PPAR-gamma-1 is a transcription factor that stimulates cell differentiation and inhibits cell growth.