In line with phosphorylation of S112 decreasing the insulin sensitizing actions of PPARγ, humans carrying a P115Q mutation, that blocks phosphorylation of serine 114 (corresponding to serine 112 in mice), are extremely obese but are also less insulin-resistant than expected based on their degree of obesity [98]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.