MAPT and Alzheimer disease: However since NH2-26–44 Tau fragment is likely to be generated during apoptosis given that the N-terminal domain of Tau contains consensus sequences suitable for cleavage by caspase(s) [28, 45], which are activated in apoptotic degenerating neurons in AD [69, 70], the possibility exists that caspase(s) gradually inhibit/s ANT as a result of NH2-Tau cleavage and the generation of toxic NH2-26–44 Tau fragment.