TNFSF10 and HIV infectious disease: The induction of FOXO3a target genes, such as Bcl-2-like 11 (BCL2L11 or Bim), TNF-related apoptosis-inducing ligand (TRAIL) and Fas ligand (FasL or CD95L), activates apoptotic intrinsic (via Bim) and extrinsic pathways [2], [3], indicating that HIV infection leads to apoptosis by the engagement of multiple apoptotic pathways.