Level of apoptosis 48 hr after HIV infection in CD4+ T-cells transduced with PPP2R1B and/or PTEN siRNAs, or treated with a PP2A inhibitor or a PTEN inhibitor were significantly reduced compared to HIV infected cells treated with ns siRNA or not treated with any compound (Figure 5F, p<0.05). The gene discussed is PTEN; the disease is HIV infectious disease.