Notably, however, we did not detect significant differential expression of such transcription factors in our microarray analysis comparing non-invasive IT and highly invasive IC2 PNETs (Dataset S1), and the expression of one prominent marker of EMT, Cdh2, was not obviously different between IT and IC2 lesions, consistent with the results of a previous study investigating determinants of the invasive phenotype using this same model of PNET [8]. The gene discussed is CDH2; the disease is primitive neuroectodermal tumor.