Lastly, cadherin 2 (Cdh2, also known as N-cadherin; MGI: 88355), a marker of epithelial-mesenchymal transition (EMT), was expressed at readily detectable and comparable levels in IT and IC1 tumors regardless of Dsp status, as well as in the IC2 tumors that did not express Cdh1 (Figure S9), consistent with the results of a previous study investigating determinants of progression to invasive carcinoma [8]; notably, there is no indication that activation of the invasive growth capability in this pathway involves an EMT, as reflected in differential expression of Cdh2 or other markers of EMT. Here, DSP is linked to invasive carcinoma.