Moreover, the expression of several desmosomal genes in addition to Cdh1 was progressively reduced in the distinctive stages of PNET tumorigenesis in RT2 mice as well as in human PNETs as compared to normal human pancreatic islets, when total lesional stages, in particular ungraded tumors, were analyzed (Figure S1) [13]. Here, CDH1 is linked to primitive neuroectodermal tumor.