TP53 and non-melanoma skin carcinoma: Interestingly, data from cutaneous HPV types (e.g., HPV5 and HPV8) associated with the development of non-melanoma skin cancer (NMSC) in the rare hereditary disease epidermodysplasia verruciformis (EV) [30], [31], [32] indicated that these viruses neither bind to, nor degrade p53.