NFKB1 and cancer: Many of the pathways show modulation in commonly observed "cancer" signatures including matrix metalloproteinases, transforming growth factors, wingless-type MMTV integration site family members (WNTs) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) downstream targets, as well as actin and myosin cytoskeletal components (data not shown and Additional Files 1, 2).