In animal studies, kallistatin gene delivery has anti-inflammatory and anti-oxidant effects, inhibiting renal inflammation including renal CAM expression in a rat renal disease model [12], inhibiting inflammation and apoptosis in acute myocardial ischemia-reperfusion injury [9], and reducing inflammation and joint injury in rat arthritis models [36]. The gene discussed is SERPINA4; the disease is myocardial ischemia.