PI3 and pancreatic insulinoma: Negative regulator of glucose-induced insulin secretion through myothrophin regulation [15]. miR-375 K/O mice are hyperglycemic -more alpha cells; less beta-cells- [17]. Regulation of PI3 pathway by regulation of PDK1 in insulinoma cells [31]. The miR-375 gene promoter directs expression selectively to endocrine pancreas [32].