Among the anti-apoptotic members of the Bcl2 family shown to be modified in HCC [23], salirasib significantly reduced Mcl1 expression in Huh7 and Hep3B but not in HepG2 cells, while Bcl-XL levels remained unchanged upon treatment in the three tested cell lines (figure 5A-B). The gene discussed is MCL1; the disease is hepatocellular carcinoma.