Earlier to the report of the panel presented here, the combination of CEA, CA125, CA 19-9, CYFRA 21-1 and NSE was the most efficacious serum test for diagnosing NSCLC, with reported test performance characteristics of a 93.8% sensitivity and 71.5% specificity (Chen et al, 2008). Here, ENO2 is linked to non-small cell lung carcinoma.