The use of ERK inhibitors in pancreatic cancer patients could therefore have no specific association with Trop2 and a specific inhibitor targeting Trop2 mediated signals would be highly desirable and could potentially augment the effects of ERK MAPK pathway inhibitors like PD0325901 and AZD6244 on pancreatic cancer cells. This evidence concerns the gene TACSTD2 and familial pancreatic carcinoma.