In an immunohistochemical analysis of Ezrin in primary breast tumors and lymph node metastases, expression levels of Ezrin protein were significantly higher in primary cancer tissues than lymph node metastases but the Ezrin staining pattern was seen mainly in the membrane region of primary cancer cells, whereas mainly in cytosols of metastatic cancer cells, indicating that the subcellular location of Ezrin protein in breast cancer is integral to the metastatic potential of the cell [44]. This evidence concerns the gene EZR and cancer.