For example, it has been shown that TRPV1 sensitivity can be significantly modulated by many of the components of the inflammatory milieu (e.g. bradykinin, and NGF) present in inflamed skin as well as by local decreases in pH [2,52-54], that in turn could result in local peptide release in the inflamed tissue contributing to neurogenic inflammation [3]. The gene discussed is TRPV1; the disease is inflammatory response.