Recent studies reported that Zn supplementation improves clinical outcomes in patients receiving radiotherapy for HNSCC,49 as well as concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma.50 The present finding that ZR attenuates the inflammatory response and restores the antitumor effect of COX-2 blockade has important clinical implications. Here, PTGS2 is linked to nasopharyngeal carcinoma.