Because simultaneous upregulation of S100A8/A9, SPRR2 and KRT6A/16/17 is a common feature of human inflammatory skin diseases such as psoriasis38 and atopic dermatitis,39 this same signature in ZD:Cox-2−/− forestomach indicates an association between inflammation and its highly hyperplastic phenotype. The gene discussed is KRT6A; the disease is atopic eczema.