S100A8/A9 have emerged as important markers for inflammation-associated cancers.32,40 They are overexpressed in many human cancers,32 including lung, colorectal, prostate, skin cancer, as well as HPV18-infected oral SCC.41 The mechanistic role of S100A8/A9 in tumor biology is emerging. Here, IGKV1D-22 is linked to skin neoplasm.