Conceptually, three approaches have exploited TERT for cancer therapy: gene therapy (using viral gene transfer to interfere telomerase activity or express suicide gene under TERT promoter), immunotherapy (stimulating TERT-specific immune response to kill TERT-expressing cells), and small-molecule inhibitors (using peptide/chemical drugs to inhibit telomerase activity) [31]. The gene discussed is TERT; the disease is cancer.