YW210.09 antibody also inhibits endogenous Wnt1 signaling in cultured tumor cells grown from MMTV-Wnt1 tumors, as observed by reduced expression of Wnt target genes Axin2 and Mmp7 to a similar extent as Fzd8CRD-Fc protein treatment (Figure 3B). Here, WNT1 is linked to neoplasm.