EZR and neoplasm: As such, Ezrin is known to mediate multiple cellular activities including survival, adhesion and migration/invasion [16]–[18], thereby regulating tumor development and progression through signal transduction pathways involving protein kinase A, Rho, phosphatidylinositol 3-kinase/Akt, mitogen-activated protein kinase (MAPK) and Src [16]–[20].