STOP null mice show behavioral deficits (disorganized activity, social withdrawal, impaired maternal behavior), hypersensitivity to amphetamine in postpubertal mice, impaired synaptic plasticity, decrease in hippocampal synaptic vesicular pools and disturbances in the dopaminergic, glutamatergic and nicotinic neurotransmissions [4]–[12] and have been proposed as a mouse model to explore the neurodevelopmental and synaptic impairment hypothesis of schizophrenia [4]. Here, MAP6 is linked to schizophrenia.