Among those with at least one ACE I allele, individuals with the BDKRB2 C181T TT or BDKRB2 C181T CT genotypes had a significantly higher hazard of cardiovascular disease as compared to those who carried the BDKRB2 C181T CC genotype (adjusted HR = 1.77, 95% CI: 1.20–2.61). Here, ACE is linked to cardiovascular disorder.