The present study suggests possible interactions between the ACE I/D and PAI-1 4G/5G polymorphisms, the BDKRB2 C181T and ACE I/D polymorphisms, the BDKRB2 exon 1 I/D and AT1R A1166C polymorphisms, and the BDKRB2 C58T and AT1R A1166C polymorphisms on the risk of cardiovascular disease. The gene discussed is SERPINE1; the disease is cardiovascular disorder.