Among those with at least one PAI-1 5G allele, there is a significantly lower hazard of cardiovascular disease associated with the presence of each ACE D allele (For PAI-1 4G5G: adjusted HR = 0.74, 95% CI: 0.60–0.92; For PAI-1 5G5G: adjusted HR = 0.49, 95% CI: 0.32–0.75). This evidence concerns the gene SERPINE1 and cardiovascular disorder.