For those with the AT1R A1166C AA genotype, individuals with the BDKRB2 exon 1 I/D +9/+9 genotype had a significantly lower hazard of cardiovascular disease as compared to those who carried either the BDKRB2 exon 1 I/D −9/+9 or −9/−9 genotypes (adjusted HR = 0.45, 95% CI: 0.24–0.82). This evidence concerns the gene AGTR1 and cardiovascular disorder.