It has reported that the sensitivity, specificity and accuracy of SCLC diagnosis by an indicator of TPS and NSE were 84.4%, 87.8%, 83.6% and 79.3%, 93.7%, 88.3%, respectively, In addition, the level of TPS and NSE in the patients' serum with metastatic SCLC were markedly higher than those in the patients with SCLC without metastasis, increased with the number of metastatic focuses [12]. The gene discussed is ENO2; the disease is small cell lung carcinoma.