Promoter hypermethylation of genes previously reported methylated in lung cancer included PRDM2, RUNX3, RARB, SCGB3A1, TWIST1, SFRP4, DLC1, SFRP5, CCND2, BCL2 and TIMP3 (Reviewed in additional file 3, Table S3). The gene discussed is RUNX3; the disease is lung carcinoma.