The genes more frequently methylated in adenocarcinomas were: RARB, TWIST1, and CACNA1A, while the most commonly methylated genes in squamous tumors were SCGB3A1, ID4, SFRP4, SFRP5, DCL1, BNIP3, H2AFX, CACNA1G, TGIF, TIMP3 and BCL2. The gene discussed is SFRP4; the disease is adenocarcinoma.