Promoter hypermethylation of genes previously reported methylated in lung cancer included PRDM2, RUNX3, RARB, SCGB3A1, TWIST1, SFRP4, DLC1, SFRP5, CCND2, BCL2 and TIMP3 (Reviewed in additional file 3, Table S3). Here, RUNX3 is linked to lung cancer.