IGHE and allergic disease: However our results introduce a caveat: although basophils play an important role in mediating allergic response and quercetin has proved to have an inhibitory action on basophils following stimulation with anti-IgE and calcium ionophore A23187, the existing bimodal effects of the flavonol and the complex nature of hypersensitivity reactions would require researchers be more cautious before considering quercetin in the practical use of the therapy and prevention of allergy.