A correlation analysis using two-sided Spearman's rank correlation test, as well as Pearson's product-moment correlation test, indicated a strong correlation between TRX1 and MIF plasma levels in patients with severe sepsis or septic shock especially at the onset of sepsis syndrome (t0: rsp = 0.720, ρ = 0.698) and 24 hours later (t24: rsp = 0.771, ρ = 0.949) (Figure 4). The gene discussed is MIF; the disease is Sepsis.