These include inflammation-related adipokines such as leptin, adiponectin, tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), procoagulant substances such as PAI-1, vasoactive substances such as leptin, angiotensinogen and endothelin, and molecules that may contribute to insulin resistance such FFA, TNF-α and resistin. This evidence concerns the gene LEP and Insulin resistance.