1 The result of experiment showed that the positive proportion of hOGG1 and HK-2 in the case group was higher than that of the control group (P < 0.05), there was no obvious differentiation for positive proportion of VDAC1 in the case group and the control group; 2 Further, statistical analysis showed that there was an increasing trend for the positive proportion of hOGG1 and HK-2 from Control, MCC, ICC to SCC in order. Here, OGG1 is linked to intrahepatic cholangiocarcinoma.