Accordingly, two key products of NFkB, namely, interleukin (IL) -1 and COX-2, a central immunological regulator of inflammation, IFN-γ, a central oncogenic factor of CRC, c-Myc, an important antiapoptotic factor, Bcl-2, and a potent angiogenic factor, IL-8, were involved. This evidence concerns the gene NFKB1 and colorectal carcinoma.