Because of the fact that IL-1 and COX-2 are products of NFkB activity [38], the current findings regarding the association of IL-1, COX-2, and IL-8 with SGMB+ve CRC confirmed the findings of a previous study conducted by our team where S. gallolyticus-seropositive CRC patients were significantly associated with higher mRNA expression of both NFkB and IL-8 [16]. The gene discussed is CXCL8; the disease is colorectal carcinoma.