The association between human haem oxygenase-1 (HO-1) and pathogenicity/severity of malaria infection was described in a few studies in vitro including molecular epidemiological investigation from brain lesion [24,29,30] and the hypothetical roles of HO-1 in pathogenesis of cerebral malaria was proposed by Shibahara [10]. Here, HMOX1 is linked to cerebral malaria.