Then we demonstrated that the mRNA expression levels and the DKK-1 protein binding capability of DKK-1binding receptors LRP5/6 and Krm1/2 in SCs from patients with MM were significantly higher than those in SCs from healthy donors and those in MM cells, and also found coculture with rhDKK-1 or MM cells in the presence or absence of a Transwell insert could up-regulate the mRNA expression of LRP5/6 and Krm1/2, and down-regulate β-catenin mRNA expression in normal human SCs. This evidence concerns the gene KREMEN1 and Miyoshi myopathy.