These mutations are at position 1644 (E/Q) in the first EGF domain and at positions 1691 (T/K), 1700 (S/N), 1701 (R/G) and 1716 (L/F) of the second EGF domain which lead to create different PfMSP-119 variants (Q/KNG/L, E/KNG/L, E/KNG/F, Q/KNG/F, E/TSR/L, Q/TSR/L, Q/TSR/F, E/TSR/F, E/TSG/L etc.)that have been reported from global malaria endemic regions. This evidence concerns the gene EGF and malaria.