Previously, we have shown that mice lacking functional Avpr1b have a reduced HPA axis response to a number of ‘chemical’ or ‘physical-emotional’ stressors, including acute LPS challenge, ethanol injection (21), acute mild restraint, forced swimming stress, change of environment (22), insulin-induced hypoglycaemia (20) and acute antidepressant administration (25), compared to their wild-type counterparts. The gene discussed is INS; the disease is Hypoglycemia.