To further test for the role of TXNIP upregulation in the lactic acidosis response, we exposed the wild type and TXNIP deficient MEF cells to the lactic acidosis conditions (10 mM lactate, pH 6.7) and performed gene expression analysis using the Affymetrix mouse 430A2 GeneChip and normalized the expression data by RMA. The gene discussed is TXNIP; the disease is lactic acidosis.