FH and von Hippel-Lindau disease: HIF-1α protein stabilization can also be seen in the development of multiple neoplasms in patients with von Hippel-Lindau disease [27] or mutations in several enzymes of the tricarboxylic acid (TCA) cycle, such as succinate dehydrogenase (SDH) and fumarate hydratase (FH) [28]–[30].