The similarity of the lactic acidosis and glucose deprivation response was observed in both induction and repression of a large number of common sets of genes, including major histocompatility complex (MHC) type I & II, DNA repair gene, alkB (alkyation repair homolog 7), and CTGF, Jun and TNF (Figure 2B), which were also seen in our previous time course experiment (Figure 1B). Here, CCN2 is linked to lactic acidosis.