Melanoma differentiation antigens (MDAs) include tyrosinase, pMEL17/gp100, gp75/tyrosinase related protein (TRP)-1, MART-1/melan-A and dopachrome tautomerase/TRP-2 and represent ideal target antigens for melanoma immunotherapy, due to preferential expression in melanocytes and melanoma cells [1]. The gene discussed is PMEL; the disease is melanoma.