An important application of serum S100B testing is the selection of patients with minor head injury who do not need further neuroradiological evaluation, as studies comparing CT (computerized tomography) scans and S100B levels have demonstrated S100B values below 0.1 ng/mL are associated with low risk of obvious neuroradiological changes (such as intracranial hemorrhage) or significant clinical sequelae [10]. This evidence concerns the gene S100B and intracranial hemorrhage.