None of the loss-loss associations were intra-chromosomal, because all associations of this type were excluded either for being located in the same broad GISTIC region or for being a CNP; indeed, more of the GISTIC peak losses were CNPs (n = 35) compared to the gains (n = 15) likely due to the unmasking effect loss of heterozygosity has on CNP detection in the tumour [29]. This evidence concerns the gene CNP and neoplasm.