However, the nsSNP, rs1990760 or Thr946Ala, in exon 15 of IFIH1, was considered the most likely functional candidate due to the highly conserved amino acid substitution and the role of IFIH1 in innate immunity, including mediating type 1 interferon production, which has been consistently reported to be associated with type 1 diabetes [1], [2], [3]. This evidence concerns the gene IFIH1 and type 1 diabetes mellitus.