SERPINE1 and cardiovascular disorder: Indeed, adipose tissue is able to secrete a number of “adipokines” [17] some of them, like resistin, leptin, adiponectin, Monocyte Chemoattractant Protein-1, Interleukin-6, angiotensinogen, angiotensin-converting enzyme, plasminogen activator inhibitor-1 (PAI-1), being implicated in cardiovascular disease [rev.