However, the linear association of RXRα mRNA levels with either Braak neuropathological stages (r = 0.193, df = 84, p = 0.076) or NP density (r = 0.132, df = 84, p = 0.225) was not significant, indicating that RXRα levels are elevated at the earliest stages of dementia and remain near maximally elevated throughout the course of dementia. The gene discussed is RXRA; the disease is dementia.