Comparisons of controls and cases presenting with varying degree of dementia or AD-associated neuropathology showed higher levels of RXRα gene expression associated with increases in CDR (F1,69 = 6.14, p = 0.008) but not with Braak neuropathological staging (F1,69 = 0.15, p = 0.703) or NP density (F1,69 = 0.52, p = 0.474; Figure 4). This evidence concerns the gene RXRA and Alzheimer disease.