Comparisons of individuals with and without AD-associated neuropathology also showed more RXRα gene expression as a function of increasing neuritic plaque (NP) density (F1,84 = 3.36, p = 0.035) but not Braak neuropathological stages (F1,84 = 1.42, p = 0.237; Figure 2). This evidence concerns the gene RXRA and Alzheimer disease.