Cetuximab and panitumumab are two MoAbs which are active against the ligand binding site of EGFR with high specificity and higher affinity for EGFR than the natural ligands TGF-α and EGF, and are now considered as one standard option for patients with advanced CRC in the first or second line of treatment [4,5]. This evidence concerns the gene EGFR and colorectal carcinoma.