In order to determine associations between BRCA1 loss and gross genomic alteration, tumor proliferation rate and gene expression profile, we have evaluated DNA ploidy and S-phase fraction by high-resolution image cytometry and gene expression profile using oligonucleotide microarrays, in a cohort of high-grade serous carcinomas with defined BRCA1 and BRCA2 status. Here, BRCA1 is linked to neoplasm.