Then, β-catenin was localized to the nucleus and transcriptionally active in MCL cell lines examined and more than half of the MCL tumors showed nuclear localization of β-catenin by immunohistochemistry, which obviously correlated with the expression of the phosphorylated/inactive form of GSK-3β(pGSK-3β)[60]. The gene discussed is GSK3B; the disease is mantle cell lymphoma.