CDKN2A and non-small cell lung carcinoma: It has been reported that wild-type CDKN2A expression from an adenovirus vector (Adv/p16) in non-small-cell lung cancer cell line A549, which carries the wild-type p53 gene, results in activation of caspase-3, accompanied by the cleavage of its substrate PARP (Koh et al, 2002).