EGFR and neoplasm: We recently analysed patients with LARC treated with preoperative CTRT and we were unable to confirm that baseline EGFR expression evaluated by IHC is a predictive factor for response as well as prognostic factor on survival; on the contrary, EGFR expression by IHC on residual tumour after preoperative chemoradiation is an independent poor prognostic factor for disease recurrence (Bertolini et al, 2007).